Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03TDN
|
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| Former ID |
DIB018510
|
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| Drug Name |
1-naphthylpiperazine
|
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| Synonyms |
1-NP
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [540008] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C14H16N2
|
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| InChI |
InChI=1S/C14H16N2/c1-2-6-13-12(4-1)5-3-7-14(13)16-10-8-15-9-11-16/h1-7,15H,8-11H2
|
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| InChIKey |
VNICFCQJUVFULD-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
5195350, 8151097, 11111754, 15195770, 24439684, 26755723, 36664359, 47216961, 47515510, 47515511, 47885589, 48185169, 48334697, 50111260, 57320874, 77298398, 85209805, 85788302, 90341223, 103086821, 103154609, 103183489, 103904019, 103920682, 104297461, 108138382, 117358857, 124750299, 124881352, 124881353, 125540784, 129499449, 129614306, 134224151, 134340784, 135081755, 135649669, 135693357, 137011689, 140305635, 162222858, 162875336, 165815772, 179235687, 184551215, 223749344, 226590908, 248606579
|
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| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 1B receptor | Target Info | Agonist | [534239] | |
| 5-hydroxytryptamine 1D receptor | Target Info | Agonist | [527380] | ||
| 5-hydroxytryptamine 6 receptor | Target Info | Agonist | [533689] | ||
| 5-hydroxytryptamine 1A receptor | Target Info | Agonist | [534528] | ||
| 5-hydroxytryptamine 1F receptor | Target Info | Antagonist | [534427] | ||
| 5-hydroxytryptamine 2B receptor | Target Info | Antagonist | [534042] | ||
| 5-hydroxytryptamine 1E receptor | Target Info | Antagonist | [526943] | ||
| 5-hydroxytryptamine 7 receptor | Target Info | Agonist | [533934] | ||
| KEGG Pathway | cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapsehsa04024:cAMP signaling pathway | |||||
| Serotonergic synapsehsa04020:Calcium signaling pathway | |||||
| Gap junction | |||||
| Serotonergic synapse | |||||
| Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway | |||||
| Serotonergic synapsehsa04014:Ras signaling pathway | |||||
| Calcium signaling pathway | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| 5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| 5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| 5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| WikiPathways | Serotonin HTR1 Group and FOS Pathway | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway | |||||
| GPCR downstream signalingWP734:Serotonin Receptor 4/6/7 and NR3C Signaling | |||||
| SIDS Susceptibility Pathways | |||||
| GPCR downstream signaling | |||||
| GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCRs, Other | |||||
| References | |||||
| Ref 526943 | Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor. Eur J Pharmacol. 2004 Jan 26;484(2-3):127-39. | ||||
| Ref 527380 | Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3630-4. | ||||
| Ref 533689 | Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol. 1993 Mar;43(3):320-7. | ||||
| Ref 533934 | Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. J Biol Chem. 1993 Nov 5;268(31):23422-6. | ||||
| Ref 534042 | Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor. Mol Pharmacol. 1993 Mar;43(3):419-26. | ||||
| Ref 534239 | Two amino acid differences in the sixth transmembrane domain are partially responsible for the pharmacological differences between the 5-HT1D beta and 5-HT1E 5-hydroxytryptamine receptors. J Neurochem. 1996 Nov;67(5):2096-103. | ||||
| Ref 534427 | Cloning and characterization of the guinea pig 5-HT1F receptor subtype: a comparison of the pharmacological profile to the human species homolog. Neuropharmacology. 1997 Apr-May;36(4-5):569-76. | ||||
| Ref 534528 | J Med Chem. 1997 Nov 21;40(24):3974-8.5-HT1B receptor antagonist properties of novel arylpiperazide derivatives of 1-naphthylpiperazine. | ||||
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