| Drug General Information |
| Drug ID |
D04ZPF
|
| Former ID |
DNC010033
|
| Drug Name |
4-(2-(2-fluoro-5-methylphenoxy)phenyl)piperidine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C18H20FNO
|
| Canonical SMILES |
CC1=CC(=C(C=C1)F)OC2=CC=CC=C2C3CCNCC3
|
| InChI |
1S/C18H20FNO/c1-13-6-7-16(19)18(12-13)21-17-5-3-2-4-15(17)14-8-10-20-11-9-14/h2-7,12,14,20H,8-11H2,1H3
|
| InChIKey |
QPPDVPUFQFPJKK-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Sodium-dependent noradrenaline transporter |
Target Info |
Inhibitor |
[1]
|
|---|
| Sodium-dependent dopamine transporter |
Target Info |
Inhibitor |
[1]
|
| Sodium-dependent serotonin transporter |
Target Info |
Inhibitor |
[1]
|
| 5-hydroxytryptamine 1A receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Dopaminergic synapse
|
|
Parkinson's disease
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Cocaine addiction
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Amphetamine addiction
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Alcoholismhsa04726:Serotonergic synapsehsa04024:cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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Serotonergic synapse
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Adrenaline and noradrenaline biosynthesisP00001:Adrenaline and noradrenaline biosynthesis
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Parkinson disease
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Dopamine receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway
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5HT2 type receptor mediated signaling pathway
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5HT3 type receptor mediated signaling pathway
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5HT4 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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5HT1 type receptor mediated signaling pathway
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Pathway Interaction Database
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Alpha-synuclein signaling
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Reactome
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Na+/Cl- dependent neurotransmitter transportersR-HSA-442660:Na+/Cl- dependent neurotransmitter transportersR-HSA-390666:Serotonin receptors
|
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G alpha (i) signalling events
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WikiPathways
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Monoamine Transport
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NRF2 pathway
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Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport
|
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Dopaminergic Neurogenesis
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Parkinsons Disease Pathway
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Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
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Neurotransmitter Clearance In The Synaptic CleftWP727:Monoamine Transport
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SIDS Susceptibility Pathways
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Synaptic Vesicle Pathway
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Serotonin Transporter ActivityWP722:Serotonin HTR1 Group and FOS Pathway
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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GPCR ligand binding
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GPCR downstream signaling
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| References |
| REF 1 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. Epub 2009 Oct 12.Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists. |
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