Drug Information

Drug General Information
Drug ID
D0Y4MC
Former ID
DIB018710
Drug Name
9-OH-risperidone
Synonyms
9-hydroxy-risperidone
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541805]
Structure
Download
2D MOL
Formula
C23H27FN4O3
InChI
InChI=1S/C23H27FN4O3/c1-14-18(23(30)28-13-17(29)3-5-21(28)25-14)8-11-27-9-6-15(7-10-27)22-19-4-2-16(24)12-20(19)31-26-22/h2,4,12,15,17,29H,3,5-11,13H2,1H3
InChIKey
ABWPQNZPAOAQSG-UHFFFAOYSA-N
PubChem Compound ID
475100
PubChem Substance ID
631818, 10307962, 38927021, 47954520, 48029712, 50271697, 103128260, 104647614, 117584510, 127383724, 135649866, 138746068, 162309163, 162793832, 164227185, 164760976, 204381780, 224951789, 226562108
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Antagonist [534281]
5-hydroxytryptamine 1A receptor Target Info Antagonist [534281]
5-hydroxytryptamine 1D receptor Target Info Antagonist [534281]
5-hydroxytryptamine 1E receptor Target Info Antagonist [534281]
Histamine H1 receptor Target Info Antagonist [534281]
5-hydroxytryptamine 1B receptor Target Info Antagonist [534281]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapsehsa04020:Calcium signaling pathway
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP04385:Histamine H1 receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling eventsR-HSA-390650:Histamine receptors
G alpha (i) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signalingWP58:Monoamine GPCRs
IL-4 Signaling Pathway
References
Ref 541805(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 67).
Ref 534281Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology (Berl). 1996 Mar;124(1-2):57-73.

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