Drug General Information
Drug ID	D08HOJ
Former ID	DNC012215
Drug Name	1,2,3,4-Tetrahydro-naphthalen-2-ylamine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[533482]
Structure		Download 2D MOL 3D MOL
Formula	C10H13N
Canonical SMILES	C1CC2=CC=CC=C2CC1N
InChI	1S/C10H13N/c11-10-6-5-8-3-1-2-4-9(8)7-10/h1-4,10H,5-7,11H2
InChIKey	LCGFVWKNXLRFIF-UHFFFAOYSA-N
PubChem Compound ID	34677
Target and Pathway
Target(s)	5-hydroxytryptamine 2A receptor	Target Info	Inhibitor	[533482]
	5-hydroxytryptamine 1A receptor	Target Info	Inhibitor	[533482]
	5-hydroxytryptamine 1D receptor	Target Info	Inhibitor	[533482]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
	Serotonergic synapsehsa04024:cAMP signaling pathway
PANTHER Pathway	5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (i) signalling events
WikiPathways	Serotonin Receptor 2 and STAT3 Signaling
	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	SIDS Susceptibility Pathways
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
	GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
References
Ref 533482	J Med Chem. 1986 Nov;29(11):2375-80.5-HT1 and 5-HT2 binding characteristics of some quipazine analogues.
Ref 533482	J Med Chem. 1986 Nov;29(11):2375-80.5-HT1 and 5-HT2 binding characteristics of some quipazine analogues.

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