TTD | Drug: D0KJ4Q

Drug General Information
Drug ID	D0KJ4Q
Former ID	DIB020634
Drug Name	p-[18F]MPPF
Synonyms	P-[18F]MPPF; [(18)F]p-MPPF
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540202]
Structure		Download 2D MOL
Formula	C24H26FN5O2
InChI	InChI=1S/C24H26FN5O2/c1-32-22-6-3-2-5-21(22)29-16-13-28(14-17-29)15-18-30(24-26-11-4-12-27-24)23(31)19-7-9-20(25)10-8-19/h2-12H,13-18H2,1H3/i25-1
InChIKey	ADELHWYAKAZUCR-FNNGWQQSSA-N
PubChem Compound ID	5352127
PubChem Substance ID	8036882, 8139834, 39378615, 75179263, 113906066, 178100284
Target and Pathway
Target(s)	5-hydroxytryptamine 1A receptor	Target Info	Antagonist	[527909]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PANTHER Pathway	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
Reactome	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	SIDS Susceptibility Pathways
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 540202	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3227).
Ref 527909	A 18F-MPPF PET normative database of 5-HT1A receptor binding in men and women over aging. J Nucl Med. 2005 Dec;46(12):1980-9.

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Drug Information