Drug Information

Drug General Information
Drug ID
D0D9YW
Former ID
DIB020901
Drug Name
SB 216641
Synonyms
SB-216,641; SB-216641
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539840]
Structure
Download
2D MOL
Formula
C28H30N4O4
InChI
InChI=1S/C28H30N4O4/c1-18-16-22(27-29-19(2)36-31-27)10-12-24(18)20-6-8-21(9-7-20)28(33)30-23-11-13-25(34-5)26(17-23)35-15-14-32(3)4/h6-13,16-17H,14-15H2,1-5H3,(H,30,33)
InChIKey
JRNUKVFYILMMLX-UHFFFAOYSA-N
PubChem Compound ID
3292447
PubChem Substance ID
4345731, 7979280, 9258802, 11113989, 14908214, 24724622, 26752130, 29215037, 34695502, 47583700, 47731203, 48029617, 48404444, 57356159, 79302524, 81065497, 85209994, 85788309, 103187949, 111868037, 128317321, 135338242, 135650988, 136351266, 162223688, 179236164, 184527989, 196408595, 225038697, 228477848, 252216261, 252433366
Target and Pathway
Target(s) 5-hydroxytryptamine 1D receptor Target Info Agonist [534475]
5-hydroxytryptamine 1A receptor Target Info Agonist [534475]
5-hydroxytryptamine 2A receptor Target Info Agonist [534475]
5-hydroxytryptamine 2B receptor Target Info Agonist [534475]
5-hydroxytryptamine 1B receptor Target Info Agonist [534475]
5-hydroxytryptamine 2C receptor Target Info Agonist [534475]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapsehsa04020:Calcium signaling pathway
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
References
Ref 539840(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 28).
Ref 534475SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20.

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