Drug General Information
Drug ID
D00UIN
Former ID
DNC009560
Drug Name
JNJ-10392980
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529569]
Structure
Download
2D MOL

3D MOL

Formula
C20H22N2O3
Canonical SMILES
C1CCN(CC1)CCOC2=CC=C(C=C2)OC3=NC4=CC=CC=C4O3
InChI
1S/C20H22N2O3/c1-4-12-22(13-5-1)14-15-23-16-8-10-17(11-9-16)24-20-21-18-6-2-3-7-19(18)25-20/h2-3,6-11H,1,4-5,12-15H2
InChIKey
ZIQGASWXUSSORV-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Potassium voltage-gated channel subfamily H member 2 Target Info Inhibitor [529569]
Leukotriene A-4 hydrolase Target Info Inhibitor [529569]
5-hydroxytryptamine 1A receptor Target Info Inhibitor [529569]
BioCyc Pathway Leukotriene biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathwayshsa04024:cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
PathWhiz Pathway Muscle/Heart ContractionPW000044:Arachidonic Acid Metabolism
Reactome Voltage gated Potassium channelsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways SIDS Susceptibility Pathways
Hematopoietic Stem Cell Differentiation
Potassium ChannelsWP2650:Arachidonic acid metabolism
Eicosanoid SynthesisWP722:Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 529569J Med Chem. 2008 Jul 24;51(14):4150-69. Epub 2008 Jun 28.Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.
Ref 529569J Med Chem. 2008 Jul 24;51(14):4150-69. Epub 2008 Jun 28.Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.

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