Drug General Information
Drug ID	D0TH8D
Former ID	DNC012242
Drug Name	8-Methoxy-2-piperazin-1-yl-quinoline
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[533482]
Structure		Download 2D MOL 3D MOL
Formula	C14H17N3O
Canonical SMILES	COC1=CC=CC2=C1N=C(C=C2)N3CCNCC3
InChI	1S/C14H17N3O/c1-18-12-4-2-3-11-5-6-13(16-14(11)12)17-9-7-15-8-10-17/h2-6,15H,7-10H2,1H3
InChIKey	CUULVNAZRYFNIT-UHFFFAOYSA-N
PubChem Compound ID	22636319
Target and Pathway
Target(s)	5-hydroxytryptamine 1D receptor	Target Info	Inhibitor	[533482]
	5-hydroxytryptamine 1A receptor	Target Info	Inhibitor	[533482]
	5-hydroxytryptamine 2A receptor	Target Info	Inhibitor	[533482]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapsehsa04024:cAMP signaling pathway
	Serotonergic synapsehsa04020:Calcium signaling pathway
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (q) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
	SIDS Susceptibility Pathways
	GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR downstream signaling
	GPCRs, Other
References
Ref 533482	J Med Chem. 1986 Nov;29(11):2375-80.5-HT1 and 5-HT2 binding characteristics of some quipazine analogues.
Ref 533482	J Med Chem. 1986 Nov;29(11):2375-80.5-HT1 and 5-HT2 binding characteristics of some quipazine analogues.

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