Drug General Information |
Drug ID |
D01MBF
|
Former ID |
DNC010035
|
Drug Name |
4-(2-fluoro-6-(4-fluorophenoxy)phenyl)piperidine
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C17H17F2NO
|
Canonical SMILES |
C1CNCCC1C2=C(C=CC=C2F)OC3=CC=C(C=C3)F
|
InChI |
1S/C17H17F2NO/c18-13-4-6-14(7-5-13)21-16-3-1-2-15(19)17(16)12-8-10-20-11-9-12/h1-7,12,20H,8-11H2
|
InChIKey |
WPYMMOOTBZOFOZ-UHFFFAOYSA-N
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PubChem Compound ID |
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Target and Pathway |
Target(s) |
Sodium-dependent noradrenaline transporter |
Target Info |
Inhibitor |
[1]
|
Sodium-dependent serotonin transporter |
Target Info |
Inhibitor |
[1]
|
5-hydroxytryptamine 1A receptor |
Target Info |
Inhibitor |
[1]
|
Sodium-dependent dopamine transporter |
Target Info |
Inhibitor |
[1]
|
KEGG Pathway
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Serotonergic synapsehsa04024:cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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Serotonergic synapsehsa04728:Dopaminergic synapse
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Parkinson's disease
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Cocaine addiction
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Amphetamine addiction
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Alcoholism
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Adrenaline and noradrenaline biosynthesisP04373:5HT1 type receptor mediated signaling pathway
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5HT2 type receptor mediated signaling pathway
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5HT3 type receptor mediated signaling pathway
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5HT4 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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5HT1 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
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Parkinson disease
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Dopamine receptor mediated signaling pathway
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Pathway Interaction Database
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Alpha-synuclein signaling
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Reactome
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Na+/Cl- dependent neurotransmitter transportersR-HSA-390666:Serotonin receptors
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G alpha (i) signalling eventsR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
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WikiPathways
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Monoamine Transport
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NRF2 pathway
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Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport
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SIDS Susceptibility Pathways
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Synaptic Vesicle Pathway
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Serotonin Transporter ActivityWP722:Serotonin HTR1 Group and FOS Pathway
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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GPCR ligand binding
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GPCR downstream signalingWP727:Monoamine Transport
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Dopaminergic Neurogenesis
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Parkinsons Disease Pathway
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Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
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Neurotransmitter Clearance In The Synaptic Cleft
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References |
REF 1 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. Epub 2009 Oct 12.Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists. |