Drug Information

Drug General Information
Drug ID
D0O3GF
Former ID
DIB018225
Drug Name
[3H]8-OH-DPAT
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540102]
Structure
Download
2D MOL
Formula
C16H25NO
InChI
InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
InChIKey
ASXGJMSKWNBENU-UHFFFAOYSA-N
PubChem Compound ID
1220
PubChem Substance ID
4548205, 7978612, 8151037, 14798544, 24263030, 24439565, 26751756, 47217012, 47515552, 47662525, 47810997, 48334740, 49689465, 49689466, 49996002, 50104448, 50104716, 53787713, 57320820, 76860501, 85208931, 85787801, 90341547, 103167491, 103806993, 103857988, 104297104, 117429498, 117617246, 124749825, 124880271, 124880272, 125702543, 125822395, 127454624, 135014291, 135649864, 135651130, 137005647, 140448617, 162914574, 163426000, 163882658, 179236036, 179425877, 184561482, 204360699, 223818122, 226812125, 241138490
Target and Pathway
Target(s) 5-hydroxytryptamine 1B receptor Target Info Agonist [525553]
5-hydroxytryptamine 1D receptor Target Info Agonist [525553]
5-hydroxytryptamine 1A receptor Target Info Agonist [525927]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
GPCR downstream signaling
References
Ref 540102(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 31).
Ref 525553Actions of roxindole at recombinant human dopamine D2, D3 and D4 and serotonin 5-HT1A, 5-HT1B and 5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1999 Jun;359(6):447-53.
Ref 525927Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines. J Med Chem. 2000 Nov 30;43(24):4701-10.

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