Drug Information

Drug General Information
Drug ID
D0Q2PF
Former ID
DIB014201
Drug Name
LY-293284
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Terminated [539199], [545514]
Company
Eli Lilly & Co
Structure
Download
2D MOL

3D MOL
Formula
C19H26N2O
InChI
InChI=1S/C19H26N2O/c1-4-8-21(9-5-2)15-10-14-12-20-18-7-6-16(13(3)22)17(11-15)19(14)18/h6-7,12,15,20H,4-5,8-11H2,1-3H3/t15-/m0/s1
InChIKey
CKYZLYQSDNLGPT-HNNXBMFYSA-N
CAS Number
CAS 141318-62-9
PubChem Compound ID
132345
PubChem Substance ID
10243094, 14922836, 29310514, 50064406, 57344109, 76036361, 81044602, 104377239, 127640464, 135088155, 135650546, 144239581, 162222457, 232579549
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Agonist [533615]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 539199(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 19).
Ref 545514Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003567)
Ref 533615Pharmacological characterization of LY293284: A 5-HT1A receptor agonist with high potency and selectivity. J Pharmacol Exp Ther. 1994 Sep;270(3):1270-81.

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