Drug Information

Drug General Information
Drug ID
D07TQV
Former ID
DAP000167
Drug Name
Lamivudine
Synonyms
DTHC; Epivir; Hepitec; Heptivir; Heptodin; Heptovir; LMV; Lamivir; Zeffix; Zefix; BCH 189; BCH189; GR109714X; GR109714X; BCH-189; BCH-790; DRG-0126; Epivir (TN); Epivir(TM); Epivir-HBV; GG-714; GR-109714X; HHA & 3TC; HHA & Lamivudine; Heptovir (TN); Lamivudine & GNA; Zeffix (TN); Epivir-HBV (TN); Lamivudine [USAN:BAN:INN]; Lamivudine [USAN:INN:BAN]; Lamivudine (JAN/USP/INN); Lamivudine, (2S-cis)-Isomer; Beta-L-2',3'-Dideoxy-3'-thiacytidine; Beta-L-3'-Thia-2',3'-dideoxycytidine; Beta-L-(-)-2',3'-dideoxy-3'-thiacytidine & Sho-Saiko-To; (+/-)-(Cis)-1-[2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine; (+/-)-3TC; (+/-)-BCH-189; (+/-)-SddC; (-)-(2'R,5'S)-1-[2'-Hydroxymethyl-5'-(1,3-oxathiolanyl)]cytosine; (-)-1-((2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine; (-)-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine; (-)-2'-Deoxy-3'-thiacytidine; (-)-BCH 189; (-)-BCH-189; (-)-NGPB-21; (-)-SddC; (-)-beta-L-2',3'-Dideoxy-3'-thiacytidine; (2R,cis)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one; 2',3' Dideoxy 3' thiacytidine; 2',3'-Dideoxy-3'-thiacytidine; 2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (+/-)-(Cis); 2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (-)-(2R,5S); 2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (-)-(2R,5S) & Galanthus Nivalis Agglutinin (GNA); 2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (-)-(2R,5S) & Hippeastrum hybrid agglutinin(HHA); 3'-Thia-2',3'-dideoxycytidine; 3TC; 3TC & GNA; 3TC & SST; 3TC (AIDS INITIATIVE) (AIDS INITIATIVE); 3TC and NV-01; 3TC, Zeffix, Heptovir, Epivir, Epivir-HBV, Lamivudine; 4-Amino-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone; 4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one; 4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one; 3TC
Drug Type
Small molecular drug
Indication HIV infection; Chronic hepatitis b [ICD9: 042, 070.2-070.3; ICD10:B16, B18.0, B18.1, B20] Approved [536361]
Therapeutic Class
Anti-HIV Agents
Company
Glaxo Smith Kline Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C8H11N3O3S
Canonical SMILES
C1C(OC(S1)CO)N2C=CC(=NC2=O)N
InChI
1S/C8H11N3O3S/c9-5-1-2-11(8(13)10-5)6-4-15-7(3-12)14-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7+/m0/s1
InChIKey
JTEGQNOMFQHVDC-NKWVEPMBSA-N
CAS Number
CAS 134678-17-4
PubChem Compound ID
60825
PubChem Substance ID
9277, 596236, 601313, 643736, 811475, 3727051, 3727058, 7847419, 7979719, 8187080, 11528367, 12014700, 12016245, 14798125, 15121620, 24277302, 26719826, 29215254, 43118163, 46386600, 46507855, 49681736, 50140269, 57314135, 81093205, 85279382, 87560180, 92308311, 92712464, 92729822, 93166191, 103195019, 103977094, 104170203, 104253324, 104321740, 117588081, 118048664, 121362453, 124658974, 124757443, 124892101, 125164247, 126584422, 126592947, 126625491, 126656696, 126665392, 127310181, 127310182
SuperDrug ATC ID
J05AF05
SuperDrug CAS ID
cas=134678174
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) HIV reverse transcriptase Target Info Modulator [556264]
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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