Drug Information

Drug General Information
Drug ID
D07UDM
Drug Name
SAR156597
Drug Type
Monoclonal antibody
Indication Idiopathic pulmonary fibrosis [ICD9: 516.3; ICD10:J84.1] Phase 2 [889407]
Company
Sanofi
Target and Pathway
Target(s) Interleukin-4 Target Info Modulator [889442]
Interleukin-13 Target Info Modulator [889442]
KEGG Pathway Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Hematopoietic cell lineage
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Intestinal immune network for IgA production
Leishmaniasis
Measles
Asthma
Autoimmune thyroid disease
Inflammatory bowel disease (IBD)
Allograft rejectionhsa04060:Cytokine-cytokine receptor interaction
NetPath Pathway TCR Signaling Pathway
TSLP Signaling PathwayNetPath_20:IL9 Signaling Pathway
IL2 Signaling Pathway
Leptin Signaling Pathway
TSLP Signaling Pathway
PANTHER Pathway Interleukin signaling pathwayP00036:Interleukin signaling pathway
Pathway Interaction Database Notch signaling pathway
IL4-mediated signaling events
CD40/CD40L signaling
IL12-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Glucocorticoid receptor regulatory network
AP-1 transcription factor network
IL2 signaling events mediated by STAT5
Calcium signaling in the CD4+ TCR pathwayreg_gr_pathway:Glucocorticoid receptor regulatory network
IL12 signaling mediated by STAT4
PathWhiz Pathway Fc Epsilon Receptor I Signaling in Mast CellsPW000453:Fc Epsilon Receptor I Signaling in Mast Cells
WikiPathways Cytokines and Inflammatory Response
Inflammatory Response Pathway
IL-4 Signaling Pathway
Spinal Cord Injury
Allograft Rejection
Folate MetabolismWP706:SIDS Susceptibility Pathways
References
Ref 889407ClinicalTrials.gov (NCT02345070) Efficacy and Safety of SAR156597 in the Treatment of Idiopathic Pulmonary Fibrosis
Ref 889442Bispecific antibodies rise again. Nat Rev Drug Discov. 2014 Nov;13(11):799-801. doi: 10.1038/nrd4478.

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