Drug Information
Drug General Information | |||||
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Drug ID |
D07WHS
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Former ID |
DNC000443
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Drug Name |
CL-316,243
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Drug Type |
Small molecular drug
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Structure |
Download2D MOL |
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Formula |
C20H20ClNO7
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InChI |
InChI=1S/C20H20ClNO7/c1-11(22-10-15(23)13-3-2-4-14(21)9-13)7-12-5-6-16-17(8-12)29-20(28-16,18(24)25)19(26)27/h2-6,8-9,11,15,22-23H,7,10H2,1H3,(H,24,25)(H,26,27)/t11-,15+/m1/s1
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InChIKey |
JEDJMKTVUPSHFW-ABAIWWIYSA-N
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CAS Number |
CAS 138908-40-4
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Mitochondrial uncoupling protein 2 | Target Info | Inducer | [538030] | |
Beta-3 adrenergic receptor | Target Info | Agonist | [535218] | ||
Mitochondrial brown fat uncoupling protein 1 | Target Info | Inducer | [538030] | ||
Mitochondrial uncoupling protein 3 | Target Info | Inducer | [538030] | ||
NetPath Pathway | IL2 Signaling Pathway | ||||
Pathway Interaction Database | FOXA2 and FOXA3 transcription factor networks | ||||
WikiPathways | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||||
Electron Transport ChainWP58:Monoamine GPCRs | |||||
Calcium Regulation in the Cardiac Cell | |||||
GPCRs, Class A Rhodopsin-like | |||||
GPCR ligand binding | |||||
GPCR downstream signalingWP236:Adipogenesis | |||||
Electron Transport ChainWP410:Diurnally Regulated Genes with Circadian Orthologs | |||||
Electron Transport Chain | |||||
References | |||||
Ref 533802 | Effect of CL-316,243, a thermogenic beta 3-agonist, on energy balance and brown and white adipose tissues in rats. Am J Physiol. 1994 Apr;266(4 Pt 2):R1371-82. | ||||
Ref 540400 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3462). | ||||
Ref 535218 | Beta 3-adrenoceptor agonists as anti-diabetic and anti-obesity drugs in humans. Curr Pharm Des. 2001 Sep;7(14):1433-49. | ||||
Ref 538030 | Anti-obesity and anti-diabetic effects of CL316,243, a highly specific beta 3-adrenoceptor agonist, in Otsuka Long-Evans Tokushima Fatty rats: induction of uncoupling protein and activation of glucose transporter 4 in white fat. Eur J Endocrinol. 1997 Apr;136(4):429-37. |
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