Target Information
Target General Infomation | |||||
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Target ID |
T69146
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Former ID |
TTDR00084
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Target Name |
Mitochondrial uncoupling protein 3
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Gene Name |
UCP3
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Synonyms |
Mitochondrial uncoupling protein 1; UCP 3; UCP3
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Target Type |
Clinical Trial
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Disease | Obesity [ICD9: 278; ICD10: E66] | ||||
Function |
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.
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BioChemical Class |
Mitochondrial carrier
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UniProt ID | |||||
Sequence |
MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRG
VLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRI LAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWK GTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDV VKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKRA LMKVQMLRESPF |
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Drugs and Mode of Action | |||||
Pathways | |||||
References |
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