Drug Information

Drug General Information
Drug ID
D08ORO
Former ID
DNC001062
Drug Name
OPC-21268
Drug Type
Small molecular drug
Indication Cardiotonic [ICD10:I50] Discontinued in Phase 2 [539395], [544608]
Structure
Download
2D MOL

3D MOL
Formula
C26H31N3O4
InChI
InChI=1S/C26H31N3O4/c1-19(30)27-15-4-18-33-23-10-7-21(8-11-23)26(32)28-16-13-22(14-17-28)29-24-6-3-2-5-20(24)9-12-25(29)31/h2-3,5-8,10-11,22H,4,9,12-18H2,1H3,(H,27,30)
InChIKey
KSNUCNRMDYJBKT-UHFFFAOYSA-N
CAS Number
CAS 131631-89-5
PubChem Compound ID
114904
PubChem Substance ID
10236546, 12014648, 14808543, 29296507, 49859189, 50970902, 57338880, 85210042, 103222371, 103938694, 104397142, 126433165, 128428427, 134340035, 134340313, 135071532, 135650773, 142385809, 162387058, 163305441, 179149803, 229514754, 241376710, 249618022, 252157642
Target and Pathway
Target(s) Vasopressin V1a receptor Target Info Antagonist [534873], [535608]
Vasopressin V1 receptor Target Info Antagonist [535809]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Reactome Vasopressin-like receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539395(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2196).
Ref 544608Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000284)
Ref 534873Nonpeptide vasopressin antagonists: a new group of hormone blockers entering the scene. Exp Clin Endocrinol Diabetes. 1999;107(3):157-65.
Ref 535608Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands. Prog Brain Res. 2002;139:197-210.
Ref 535809Vasopressin (ADH). Nippon Rinsho. 1992 Dec;50(12):2893-900.

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