Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T29999
|
||||
| Former ID |
TTDR00176
|
||||
| Target Name |
Vasopressin V1 receptor
|
||||
| Synonyms |
ADH V1 receptor
|
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| Target Type |
Successful
|
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| Disease | Amnesia [ICD10: F04] | ||||
| Cardiotonic [ICD10: I50] | |||||
| Hyponatraemia [ICD10: E87.1] | |||||
| Drugs and Mode of Action | |||||
| Drug(s) | Lypressin | Drug Info | Approved | Amnesia | [1], [2] |
| OPC-31260 | Drug Info | Approved | Hyponatraemia | [3], [2] | |
| OPC-21268 | Drug Info | Discontinued in Phase 2 | Cardiotonic | [4], [5] | |
| Modulator | Lypressin | Drug Info | [6], [2] | ||
| Antagonist | OPC-21268 | Drug Info | [7] | ||
| OPC-31260 | Drug Info | [7] | |||
| Agonist | Triglycyl-lysine-vasopressin | Drug Info | [8] | ||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2172). | ||||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
| REF 3 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001739) | ||||
| REF 4 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2196). | ||||
| REF 5 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000284) | ||||
| REF 6 | Human pain thresholds after the application of lypressin, a vasopressin analogue. Pharmacol Toxicol. 1987 Jul;61(1):16-9. | ||||
| REF 7 | Vasopressin (ADH). Nippon Rinsho. 1992 Dec;50(12):2893-900. | ||||
| REF 8 | Evidence in hyponatremia related to inappropriate secretion of ADH that V1 receptor stimulation contributes to the increase in renal uric acid clearance. J Am Soc Nephrol. 1996 May;7(5):805-10. | ||||
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