Drug Information

Drug General Information
Drug ID
D0A9SA
Former ID
DNCL002792
Drug Name
Canfosfamide
Synonyms
Telcyta (TN)
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 3 [532490]
Company
Telik
Structure
Download
2D MOL

3D MOL
Formula
C26H41Cl5N5O10PS
Canonical SMILES
C1=CC=C(C=C1)C(C(=O)O)NC(=O)C(CS(=O)(=O)CCOP(=O)(N(CCCl<br />)CCCl)N(CCCl)CCCl)NC(=O)CCC(C(=O)O)N.Cl
InChI
1S/C26H40Cl4N5O10PS.ClH/c27-8-12-34(13-9-28)46(42,35(14-10-29)15-11-30)45-16-17-47(43,44)18-21(32-22(36)7-6-20(31)25(38)39)24(37)33-23(26(40)41)19-4-2-1-3-5-19;/h1-5,20-21,23H,6-18,31H2,(H,32,36)(H,33,37)(H,38,39)(H,40,41);1H/t20-,21+,23+;/m0./s1
InChIKey
NECZZOFFLFZNHL-FJKQHKIKSA-N
PubChem Compound ID
23724863
PubChem Substance ID
57388092
Target and Pathway
Target(s) Glutathione S-transferase P Target Info Modulator [527097], [532490]
BioCyc Pathway Glutathione-mediated detoxification
4-hydroxy-2-nonenal detoxification
KEGG Pathway Glutathione metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Pathways in cancer
Chemical carcinogenesis
Prostate cancer
NetPath Pathway TCR Signaling Pathway
References
Ref 532490Mechanism of glutathione transferase P1-1-catalyzed activation of the prodrug canfosfamide (TLK286, TELCYTA). Biochemistry. 2013 Nov 12;52(45):8069-78.
Ref 527097Phase 1 study of TLK286 (Telcyta) administered weekly in advanced malignancies. Clin Cancer Res. 2004 Jun 1;10(11):3689-98.
Ref 532490Mechanism of glutathione transferase P1-1-catalyzed activation of the prodrug canfosfamide (TLK286, TELCYTA). Biochemistry. 2013 Nov 12;52(45):8069-78.

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