Target Information
Target General Infomation | |||||
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Target ID |
T21669
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Former ID |
TTDI02088
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Target Name |
Glutathione S-transferase P
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Gene Name |
GSTP1
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Synonyms |
GST classpi; GSTP11; GSTP1
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Target Type |
Clinical Trial
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Disease | Myelodysplastic syndrome [ICD9: 238.7; ICD10: D46] | ||||
Solid tumours [ICD9: 140-199, 210-229; ICD10: C00-D48] | |||||
Function |
Conjugation of reducedglutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
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BioChemical Class |
Alkyl aryl transferase
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UniProt ID | |||||
EC Number |
EC 2.5.1.18
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Sequence |
MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGD
LTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYV KALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAY VGRLSARPKLKAFLASPEYVNLPINGNGKQ |
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Drugs and Mode of Action | |||||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
References |
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