TTD | Drug: D0F5VD

Drug General Information
Drug ID	D0F5VD
Former ID	DNCL003497
Drug Name	Ezatiostat
Synonyms	Telintra (TN)
Drug Type	Small molecular drug
Indication	Myelodysplastic syndrome [ICD9: 238.7; ICD10:D46]		Phase 2	[523599]
Company	Telik
Structure		Download 2D MOL 3D MOL
Formula	C27H35N3O6S
Canonical SMILES	CCOC(=O)C(CCC(=O)NC(CSCC1=CC=CC=C1)C(=O)NC(C2=CC=CC=C2)<br />C(=O)OCC)N
InChI	1S/C27H35N3O6S/c1-3-35-26(33)21(28)15-16-23(31)29-22(18-37-17-19-11-7-5-8-12-19)25(32)30-24(27(34)36-4-2)20-13-9-6-10-14-20/h5-14,21-22,24H,3-4,15-18,28H2,1-2H3,(H,29,31)(H,30,32)/t21-,22-,24+/m0/s1
InChIKey	GWEJFLVSOGNLSS-WPFOTENUSA-N
PubChem Compound ID	5310939
PubChem Substance ID	7978478, 11056156, 14934362, 39340685, 50496464, 76715674, 114154887, 131549348, 135199823, 137276065, 175427010, 198941834, 210274912, 210280547, 226746033, 242060299, 242549601, 251963063, 251970957, 252449233, 252478825
Target and Pathway
Target(s)	Glutathione S-transferase P	Target Info	Modulator	[550407]
BioCyc Pathway	Glutathione-mediated detoxification
BioCyc Pathway	4-hydroxy-2-nonenal detoxification
KEGG Pathway	Glutathione metabolism
	Metabolism of xenobiotics by cytochrome P450
	Drug metabolism - cytochrome P450
	Pathways in cancer
	Chemical carcinogenesis
	Prostate cancer
NetPath Pathway	TCR Signaling Pathway
References
Ref 523599	ClinicalTrials.gov (NCT01422486) Phase 2 Study of Telintra in Deletion 5q Myelodysplastic Syndrome. U.S. National Institutes of Health.
Ref 550407	National Cancer Institute Drug Dictionary (drug id 485244).

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Drug Information