Drug Information

Drug General Information
Drug ID
D0B0NO
Former ID
DIB020827
Drug Name
RO116-4875/608
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542815]
Structure
Download
2D MOL
Formula
C27H37Cl2N3O4
InChI
InChI=1S/C27H37Cl2N3O4/c1-17(2)23(31-27(33)30-20-14-24(34-3)26(36-5)25(15-20)35-4)16-32-10-8-18(9-11-32)12-19-6-7-21(28)22(29)13-19/h6-7,13-15,17-18,23H,8-12,16H2,1-5H3,(H2,30,31,33)/t23-/m0/s1
InChIKey
FQHUEFRHSWYBQS-QHCPKHFHSA-N
PubChem Compound ID
10098735
PubChem Substance ID
15086127, 22507772, 39158608, 76977985, 135650912, 223821489, 227455909, 244089495
Target and Pathway
Target(s) mRNA of CCR3 chemokine Target Info Antagonist [526363]
NetPath Pathway IL3 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
References
Ref 542815(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 789).
Ref 526363Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists. Am J Respir Crit Care Med. 2002 Jun 15;165(12):1602-9.

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