Drug Information

Drug General Information
Drug ID
D0C5FN
Former ID
DIB020846
Drug Name
Rp-5-OMe-UDPalphaB
Synonyms
5-OMe-uridine-5'-O-(alpha-boranodiphosphate); compound 18a [PMID: 22901672]
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532006]
Structure
Download
2D MOL
Formula
C10H17BN2O12P2-
InChI
InChI=1S/C10H20BN2O12P2/c1-22-4-2-13(10(17)12-8(4)16)9-7(15)6(14)5(24-9)3-23-26(11,18)25-27(19,20)21/h4-7,9,14-15H,2-3H2,1,11H3,(H,12,16,17)(H2,19,20,21)/q-1/t4?,5-,6+,7+,9?,26-/m1/s1
InChIKey
YXHXVAMQDBFYRD-ANTPIODHSA-N
PubChem Compound ID
73755169
PubChem Substance ID
178102533
Target and Pathway
Target(s) P2Y purinoceptor 6 Target Info Agonist [532861]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome G alpha (q) signalling events
P2Y receptors
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 532006UDP made a highly promising stable, potent, and selective P2Y6-receptor agonist upon introduction of a boranophosphate moiety. Bioorg Med Chem. 2012 Sep 15;20(18):5483-95.
Ref 5328615-OMe-uridine-5'-O-(alpha-boranodiphosphate), a novel nucleotide derivative highly active at the human P2Y(6) receptor protects against death-receptor mediated glial apoptosis. Neurosci Lett. 2014 Aug 22;578:80-4.

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