Drug General Information |
Drug ID |
D0D2YR
|
Former ID |
DNC011605
|
Drug Name |
9-Methyl-2,3,4,9-tetrahydro-1H-beta-carboline
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C12H14N2
|
Canonical SMILES |
CN1C2=C(CCNC2)C3=CC=CC=C31
|
InChI |
1S/C12H14N2/c1-14-11-5-3-2-4-9(11)10-6-7-13-8-12(10)14/h2-5,13H,6-8H2,1H3
|
InChIKey |
STMNLEHELVDDKF-UHFFFAOYSA-N
|
PubChem Compound ID |
|
Target and Pathway |
Target(s) |
Amine oxidase [flavin-containing] A |
Target Info |
Inhibitor |
[1]
|
Amine oxidase [flavin-containing] B |
Target Info |
Inhibitor |
[1]
|
BioCyc Pathway
|
Superpathway of tryptophan utilization
|
Dopamine degradation
|
Putrescine degradation III
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Noradrenaline and adrenaline degradation
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Serotonin degradation
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Superpathway of melatonin degradation
|
Melatonin degradation IIPWY66-401:Superpathway of tryptophan utilization
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Tryptophan degradation via tryptamine
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KEGG Pathway
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Glycine, serine and threonine metabolism
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Arginine and proline metabolism
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Histidine metabolism
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Tyrosine metabolism
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Phenylalanine metabolism
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Tryptophan metabolism
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Drug metabolism - cytochrome P450
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Metabolic pathways
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Serotonergic synapse
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Dopaminergic synapse
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Cocaine addiction
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Amphetamine addiction
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Alcoholismhsa00260:Glycine, serine and threonine metabolism
|
Alcoholism
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NetPath Pathway
|
IL4 Signaling Pathway
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PANTHER Pathway
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Adrenaline and noradrenaline biosynthesis
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5-Hydroxytryptamine degredation
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Dopamine receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
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Dopamine receptor mediated signaling pathway
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Pathway Interaction Database
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Alpha-synuclein signaling
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PathWhiz Pathway
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Histidine Metabolism
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Tyrosine Metabolism
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Glycine and Serine Metabolism
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Reactome
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Norepinephrine Neurotransmitter Release Cycle
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WikiPathways
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SIDS Susceptibility Pathways
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Biogenic Amine Synthesis
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Oxidative Stress
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Dopamine metabolism
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Phase 1 - Functionalization of compounds
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Neurotransmitter Release Cycle
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Neurotransmitter Clearance In The Synaptic Cleft
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Serotonin Transporter ActivityWP465:Tryptophan metabolism
|
References |
REF 1 | Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. |