Drug General Information
Drug ID
D0D9BB
Former ID
DNC007709
Drug Name
1-benzhydryl-4-(pyridin-2-yl)piperidin-4-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528781]
Structure
Download
2D MOL

3D MOL

Formula
C23H24N2O
Canonical SMILES
C1CN(CCC1(C2=CC=CC=N2)O)C(C3=CC=CC=C3)C4=CC=CC=C4
InChI
1S/C23H24N2O/c26-23(21-13-7-8-16-24-21)14-17-25(18-15-23)22(19-9-3-1-4-10-19)20-11-5-2-6-12-20/h1-13,16,22,26H,14-15,17-18H2
InChIKey
RQPLUPANAPAMMF-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Kappa-type opioid receptor Target Info Inhibitor [528781]
Nociceptin receptor Target Info Inhibitor [528781]
Mu-type opioid receptor Target Info Inhibitor [528781]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Opioid prodynorphin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Enkephalin release
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signalingWP69:TCR Signaling Pathway
Opioid Signalling
GPCR downstream signaling
References
Ref 528781Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2.
Ref 528781Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2.

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