Drug General Information |
Drug ID |
D0DB7A
|
Former ID |
DNC008809
|
Drug Name |
9-Isopropyl-9H-adenine
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C8H11N5
|
Canonical SMILES |
CC(C)N1C=NC2=C1N=CN=C2N
|
InChI |
1S/C8H11N5/c1-5(2)13-4-12-6-7(9)10-3-11-8(6)13/h3-5H,1-2H3,(H2,9,10,11)
|
InChIKey |
BCMZIPWCRGOWEV-UHFFFAOYSA-N
|
PubChem Compound ID |
|
Target and Pathway |
Target(s) |
Adenosine A1 receptor |
Target Info |
Inhibitor |
[1]
|
Adenosine A2b receptor |
Target Info |
Inhibitor |
[1]
|
Adenosine A2a receptor |
Target Info |
Inhibitor |
[1]
|
KEGG Pathway
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cGMP-PKG signaling pathway
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cAMP signaling pathway
|
Sphingolipid signaling pathway
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Neuroactive ligand-receptor interaction
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Morphine addictionhsa04015:Rap1 signaling pathway
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Calcium signaling pathway
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Vascular smooth muscle contraction
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Alcoholismhsa04015:Rap1 signaling pathway
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Parkinson's disease
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Alcoholism
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NetPath Pathway
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TCR Signaling Pathway
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RANKL Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Pathway Interaction Database
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C-MYB transcription factor networkhif2pathway:HIF-2-alpha transcription factor network
|
PathWhiz Pathway
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Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
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Reactome
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Adenosine P1 receptors
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G alpha (i) signalling eventsR-HSA-417973:Adenosine P1 receptors
|
G alpha (s) signalling events
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Surfactant metabolismR-HSA-187024:NGF-independant TRKA activation
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Surfactant metabolism
|
WikiPathways
|
Nucleotide GPCRs
|
GPCRs, Class A Rhodopsin-like
|
GPCR ligand binding
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GPCR downstream signalingWP80:Nucleotide GPCRs
|
Monoamine Transport
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NGF signalling via TRKA from the plasma membrane
|
GPCR downstream signaling
|
GPCRs, Other
|
References |
REF 1 | Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. Epub 2009 Feb 23.8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. |