Drug Information

Drug General Information
Drug ID
D0F1EX
Former ID
DAP000415
Drug Name
Alclometasone
Synonyms
Aclometasone; Aclovate (TN); Alclometasone (INN); Alclometasone [INN:BAN]; (7R,8S,9S,10R,11S,13S,14S,16R,17R)-7-chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one; (7alpha,11beta,16alpha)-7-chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 7alpha-Chloro-16alpha-methylprednisolone
Drug Type
Small molecular drug
Indication Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25] Approved [536361]
Therapeutic Class
Antiinflammatory Agents
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C22H29ClO5
Canonical SMILES
CC1CC2C3C(CC4=CC(=O)C=CC4(C3C(CC2(C1(C(=O)CO)O)C)O)C)Cl
InChI
1S/C22H29ClO5/c1-11-6-14-18-15(23)8-12-7-13(25)4-5-20(12,2)19(18)16(26)9-21(14,3)22(11,28)17(27)10-24/h4-5,7,11,14-16,18-19,24,26,28H,6,8-10H2,1-3H3/t11-,14+,15-,16+,18-,19+,20+,21+,22+/m1/s1
InChIKey
FJXOGVLKCZQRDN-PHCHRAKRSA-N
CAS Number
CAS 66734-13-2
PubChem Compound ID
5311000
PubChem Substance ID
7978656, 11056200, 15451271, 39340733, 46508296, 51071561, 51091455, 87246635, 114155019, 124963548, 135199337, 135834189, 137019440, 137234003, 141792513, 162258587, 164838234, 175265310, 180371900, 226396178, 252562151
SuperDrug ATC ID
D07AB10; S01BA10
SuperDrug CAS ID
cas=066734132
Target and Pathway
Target(s) Corticosteroid-binding globulin Target Info Binder [537683]
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 537683The anti-inflammatory effects of LY178002 and LY256548. Agents Actions. 1989 Jun;27(3-4):300-2.

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