Drug Information

Drug General Information
Drug ID
D0F3EO
Former ID
DNCL002453
Drug Name
HS-110
Drug Type
Vaccine
Indication Non-small cell lung cancer [ICD10:C33-C34] Phase 2 [524720]
Company
Heat Biologics
Target and Pathway
Target(s) T-lymphocyte activation antigen CD80 Target Info [550978]
Endoplasmin Target Info [550978]
KEGG Pathway Cell adhesion molecules (CAMs)
Toll-like receptor signaling pathway
Intestinal immune network for IgA production
Type I diabetes mellitus
Autoimmune thyroid disease
Systemic lupus erythematosus
Rheumatoid arthritis
Allograft rejection
Graft-versus-host disease
Viral myocarditishsa04141:Protein processing in endoplasmic reticulum
PI3K-Akt signaling pathway
NOD-like receptor signaling pathway
Estrogen signaling pathway
Thyroid hormone synthesis
Pathways in cancer
Prostate cancer
NetPath Pathway Leptin Signaling Pathway
RANKL Signaling PathwayNetPath_23:TSH Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway T cell activation
Pathway Interaction Database TCR signaling in na&#xef
TCR signaling in na&#xef
IL12 signaling mediated by STAT4il6_7pathway:IL6-mediated signaling events
Reactome PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signalingR-HSA-1679131:Trafficking and processing of endosomal TLR
Scavenging by Class A Receptors
WikiPathways Toll-like receptor signaling pathway
Inflammatory Response Pathway
PIP3 activates AKT signaling
Primary Focal Segmental Glomerulosclerosis FSGS
Allograft Rejection
Costimulation by the CD28 family
Regulation of toll-like receptor signaling pathwayWP706:SIDS Susceptibility Pathways
Binding and Uptake of Ligands by Scavenger Receptors
Trafficking and processing of endosomal TLR
Activation of Chaperone Genes by ATF6-alpha
References
Ref 524720ClinicalTrials.gov (NCT02117024) A Phase 2 Study of Viagenpumatucel-L (HS-110) in Patients With Non-Small Cell Lung Cancer. U.S. National Institutes of Health.
Ref 550978Clinical pipeline report, company report or official report of Heat Biologics.

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