Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T81311
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| Former ID |
TTDI01987
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| Target Name |
Endoplasmin
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| Gene Name |
HSP90B1
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| Synonyms |
94 kDa glucoseregulated protein; GRP94; Heat shock protein 90 kDa beta member 1; Tumor rejection antigen 1; gp96 homolog; HSP90B1
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| Target Type |
Clinical Trial
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| Disease | Non-small cell lung cancer [ICD10: C33-C34] | ||||
| Function |
Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.
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| BioChemical Class |
Heat shock protein
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| UniProt ID | |||||
| Sequence |
MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDG
LNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISL TDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTE AQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNT LGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAK EEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYK SFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITD DFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKY NDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYF MAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDE SEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMER IMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFET ATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDE EMDVGTDEEEETAKESTAEKDEL |
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| Drugs and Mode of Action | |||||
| Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
| TEP | EXP Info | ||||
| Pathways | |||||
| KEGG Pathway | Protein processing in endoplasmic reticulum | ||||
| PI3K-Akt signaling pathway | |||||
| NOD-like receptor signaling pathway | |||||
| Estrogen signaling pathway | |||||
| Thyroid hormone synthesis | |||||
| Pathways in cancer | |||||
| Prostate cancer | |||||
| NetPath Pathway | TSH Signaling Pathway | ||||
| TCR Signaling Pathway | |||||
| Pathway Interaction Database | IL6-mediated signaling events | ||||
| Reactome | Trafficking and processing of endosomal TLR | ||||
| Scavenging by Class A Receptors | |||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Binding and Uptake of Ligands by Scavenger Receptors | |||||
| Trafficking and processing of endosomal TLR | |||||
| Activation of Chaperone Genes by ATF6-alpha | |||||
| References | |||||
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