Drug General Information
Drug ID	D0G5SU
Former ID	DIB001155
Drug Name	Paquinimod
Synonyms	ABR-215757; ABR-25757; Project 57-57, Active Biotech
Drug Type	Small molecular drug
Indication	Lupus [ICD9: 710; ICD10:M32]		Phase 2	[523718]
Company	Active Biotech AB
Structure		Download 2D MOL 3D MOL
Formula	C21H22N2O3
Canonical SMILES	c12c(n(c(=O)c(c1O)C(=O)N(c1ccccc1)CC)C)cccc2CC
CAS Number	CAS 248282-01-1
PubChem Compound ID	54684617
Target and Pathway
Target(s)	Calgranulin B	Target Info	Inhibitor	[533239]
Pathway Interaction Database	Endogenous TLR signaling
WikiPathways	Vitamin D Receptor Pathway
	IL1 and megakaryotyces in obesity
References
Ref 523718	ClinicalTrials.gov (NCT01487551) An Open-Label Study to Evaluate Biomarkers and Safety in Systemic Sclerosis Patients Treated With ABR-215757 (Paquinimod). U.S. National Institutes of Health.
Ref 533239	Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis. Ann Rheum Dis. 2015 May 12. pii: annrheumdis-2014-206517.

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