Drug Information

Drug General Information
Drug ID
D0G7DF
Former ID
DNC007506
Drug Name
4-phenyl-1-(phenyl(m-tolyl)methyl)piperidin-4-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528785]
Structure
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2D MOL

3D MOL
Formula
C25H27NO
Canonical SMILES
CC1=CC(=CC=C1)C(C2=CC=CC=C2)N3CCC(CC3)(C4=CC=CC=C4)O
InChI
1S/C25H27NO/c1-20-9-8-12-22(19-20)24(21-10-4-2-5-11-21)26-17-15-25(27,16-18-26)23-13-6-3-7-14-23/h2-14,19,24,27H,15-18H2,1H3
InChIKey
ODFDCTDNLNJAAY-UHFFFAOYSA-N
PubChem Compound ID
44426827
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Inhibitor [528785]
Nociceptin receptor Target Info Inhibitor [528785]
Delta-type opioid receptor Target Info Inhibitor [528785]
Kappa-type opioid receptor Target Info Inhibitor [528785]
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addictionhsa04080:Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin releaseP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Opioid prodynorphin pathway
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
References
Ref 528785Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1.
Ref 528785Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1.

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