Drug Information

Drug General Information
Drug ID
D0H0AO
Former ID
DNC010350
Drug Name
Phenyl 7-methoxy-4-phenylbenzofuran-2-ylcarbamate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530599]
Structure
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2D MOL

3D MOL
Formula
C22H17NO4
Canonical SMILES
COC1=C2C(=C(C=C1)C3=CC=CC=C3)C=C(O2)NC(=O)OC4=CC=CC=C4
InChI
1S/C22H17NO4/c1-25-19-13-12-17(15-8-4-2-5-9-15)18-14-20(27-21(18)19)23-22(24)26-16-10-6-3-7-11-16/h2-14H,1H3,(H,23,24)
InChIKey
LJHDOOYWZIWTJW-UHFFFAOYSA-N
PubChem Compound ID
46230983
Target and Pathway
Target(s) Adenosine A2a receptor Target Info Inhibitor [530599]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Parkinson's disease
Alcoholism
Pathway Interaction Database HIF-2-alpha transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome NGF-independant TRKA activation
Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
Monoamine Transport
GPCRs, Class A Rhodopsin-like
NGF signalling via TRKA from the plasma membrane
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 530599Bioorg Med Chem Lett. 2010 Feb 1;20(3):1090-3. Epub 2009 Dec 11.Synthetic studies on selective adenosine A2A receptor antagonists: synthesis and structure-activity relationships of novel benzofuran derivatives.
Ref 530599Bioorg Med Chem Lett. 2010 Feb 1;20(3):1090-3. Epub 2009 Dec 11.Synthetic studies on selective adenosine A2A receptor antagonists: synthesis and structure-activity relationships of novel benzofuran derivatives.

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