Drug Information

Drug General Information
Drug ID
D0H5DU
Former ID
DAP000835
Drug Name
Oxyphencyclimine
Synonyms
Antulcus; Caridan; Daricol; Manir; Naridan; Oxifencicliminum; Oxiphencycliminum; Oxyphencycliminum; Zamanil; Oxifencicliminum [INN-Spanish]; Oxyphencyclimine (INN); Oxyphencyclimine [INN:BAN]; Oxyphencycliminum [INN-Latin]; Benzeneacetic acid, .alpha.-cyclohexyl-.alpha.-hydroxy-, (1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)methyl ester; (1-methyl-1,4,5,6-tetrahydropyrimidin-2-yl)methyl cyclohexyl(hydroxy)phenylacetate; (1-methyl-5,6-dihydro-4H-pyrimidin-2-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate; 1,4,5,6-Tetrahydro-1-methyl-2-pyrimidinemethanol-alpha-phenylcyclohexaneglycolate; 1,4,5,6-Tetrahydro-1-methyl-2-pyrimidinylmethyl alpha-cyclohexyl-alpha-phenylglycolat; 1-Methyl-1,4,5,6-tetrahydro-2-pyrimidinylmethyl-alpha-cyclohexylmandelat
Drug Type
Small molecular drug
Indication Peptic ulcer [ICD9: 531-534; ICD10:K25-K27] Approved [542274], [550780], [551871]
Therapeutic Class
Anticholinergic Agents
Company
Pfizer Laboratories Div Pfizer Inc
Structure
Download
2D MOL

3D MOL
Formula
C20H28N2O3
InChI
InChI=1S/C20H28N2O3/c1-22-14-8-13-21-18(22)15-25-19(23)20(24,16-9-4-2-5-10-16)17-11-6-3-7-12-17/h2,4-5,9-10,17,24H,3,6-8,11-15H2,1H3
InChIKey
DUDKAZCAISNGQN-UHFFFAOYSA-N
CAS Number
CAS 125-53-1
PubChem Compound ID
4642
PubChem Substance ID
10053, 4487440, 7980239, 8152853, 10506089, 11336051, 11361290, 11364500, 11367062, 11369624, 11372991, 11374066, 11377786, 11462262, 11485336, 11489416, 11491621, 11492049, 11495420, 14900524, 29223731, 46507487, 47736543, 47885471, 48334559, 48416369, 50064292, 50300966, 57322371, 85209614, 96025012, 103556001, 103828063, 104307000, 117579805, 124883477, 125823083, 134338115, 134973031, 137009682, 160963730, 178103830, 179038967, 223440573, 226599461, 243595747, 250067444
SuperDrug ATC ID
A03AA01
SuperDrug CAS ID
cas=000125531
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M5 Target Info Binder [535829]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 542274(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7256).
Ref 550780Drug information of Oxyphencyclimine, 2008. eduDrugs.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535829Stereoselective interaction of procyclidine, hexahydro-difenidol, hexbutinol and oxyphencyclimine, and of related antagonists, with four muscarinic receptors. Eur J Pharmacol. 1992 Sep 1;227(1):33-42.

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