Drug Information

Drug General Information
Drug ID
D0H7PW
Former ID
DNC014176
Drug Name
PIPERINE
Drug Type
Small molecular drug
Indication Vitiligo [ICD9: 709.01; ICD10:L80] Phase 1/2 [523529], [539613]
Structure
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2D MOL

3D MOL
Formula
C17H19NO3
InChI
InChI=1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+
InChIKey
MXXWOMGUGJBKIW-YPCIICBESA-N
PubChem Compound ID
638024
PubChem Substance ID
6615, 84021, 589162, 1916561, 3134289, 8138057, 8144276, 8149678, 8704601, 10321424, 10538527, 10584664, 11537714, 14775491, 24898568, 24901388, 26531569, 26612115, 26680012, 26748436, 26748437, 26753730, 29204493, 43760287, 47365277, 47440351, 47662373, 47885490, 47959849, 48110525, 48259326, 48414997, 48423957, 49698510, 49748464, 49856282, 50107401, 50107402, 53789346, 53801087, 56463241, 57394548, 57407729, 78531100, 81065204, 81092942, 85272433, 87574654, 88802195, 92124496
Target and Pathway
Target(s) Amine oxidase [flavin-containing] A Target Info Inhibitor [530562]
Amine oxidase [flavin-containing] B Target Info Inhibitor [530562]
BioCyc Pathway Superpathway of tryptophan utilization
Dopamine degradation
Putrescine degradation III
Noradrenaline and adrenaline degradation
Serotonin degradation
Superpathway of melatonin degradation
Melatonin degradation IIPWY66-401:Superpathway of tryptophan utilization
Tryptophan degradation via tryptamine
KEGG Pathway Glycine, serine and threonine metabolism
Arginine and proline metabolism
Histidine metabolism
Tyrosine metabolism
Phenylalanine metabolism
Tryptophan metabolism
Drug metabolism - cytochrome P450
Metabolic pathways
Serotonergic synapse
Dopaminergic synapse
Cocaine addiction
Amphetamine addiction
Alcoholismhsa00260:Glycine, serine and threonine metabolism
Alcoholism
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
5-Hydroxytryptamine degredation
Dopamine receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Dopamine receptor mediated signaling pathway
Pathway Interaction Database Alpha-synuclein signaling
PathWhiz Pathway Histidine Metabolism
Tyrosine Metabolism
Glycine and Serine Metabolism
Reactome Norepinephrine Neurotransmitter Release Cycle
WikiPathways SIDS Susceptibility Pathways
Biogenic Amine Synthesis
Oxidative Stress
Dopamine metabolism
Phase 1 - Functionalization of compounds
Neurotransmitter Release Cycle
Neurotransmitter Clearance In The Synaptic Cleft
Serotonin Transporter ActivityWP465:Tryptophan metabolism
References
Ref 523529ClinicalTrials.gov (NCT01383694) Effect Of Piperine In Patients With Oropharyngeal Dysphagia. U.S. National Institutes of Health.
Ref 539613(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2489).
Ref 530562Bioorg Med Chem Lett. 2010 Jan 15;20(2):537-40. Epub 2009 Nov 26.Proposed structural basis of interaction of piperine and related compounds with monoamine oxidases.

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