Drug General Information
Drug ID
Former ID
Drug Name
2'-Monophosphoadenosine 5'-Diphosphoribose
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551393]


Canonical SMILES
C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C<br />(C(C(O3)N4C=NC5=C4N=CN=C5N)OP(=O)(O)O)O)O)O)C(=O)N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Dihydrofolate reductase Target Info Inhibitor [551393]
Aspartate-semialdehydedehydrogenase Target Info Inhibitor [551393]
Aldo-keto reductase family 1 member C3 Target Info Inhibitor [551393]
Aldose reductase Target Info Inhibitor [551393]
Glucose-6-phosphate dehydrogenase Target Info Inhibitor [551393]
Corticosteroid 11-beta-dehydrogenase, isozyme 1 Target Info Inhibitor [551393]
3-hydroxy-3-methylglutaryl-coenzyme A reductase Target Info Inhibitor [551393]
Alcohol dehydrogenase Target Info Inhibitor [551393]
Nitric-oxide synthase, brain Target Info Inhibitor [551393]
Estradiol 17 beta-dehydrogenase 1 Target Info Inhibitor [551393]
BioCyc Pathway Superpathway of steroid hormone biosynthesis
Allopregnanolone biosynthesis
Androgen biosynthesisPWY-5453:Methylglyoxal degradation III
Acetone degradation I (to methylglyoxal)PENTOSE-P-PWY:Pentose phosphate pathway
Pentose phosphate pathway (oxidative branch)PWY-5910:Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
Superpathway of cholesterol biosynthesis
Mevalonate pathwayPWY66-401:Superpathway of tryptophan utilization
Tryptophan degradation via tryptaminePWY-4983:Citrulline-nitric oxide cyclePWY-7305:Superpathway of steroid hormone biosynthesis
Estradiol biosynthesis I
KEGG Pathway Steroid hormone biosynthesis
Arachidonic acid metabolism
Metabolic pathways
Ovarian steroidogenesishsa00040:Pentose and glucuronate interconversions
Fructose and mannose metabolism
Galactose metabolism
Glycerolipid metabolism
Metabolic pathwayshsa00030:Pentose phosphate pathway
Glutathione metabolism
Biosynthesis of antibiotics
Carbon metabolism
Central carbon metabolism in cancerhsa00140:Steroid hormone biosynthesis
Metabolism of xenobiotics by cytochrome P450
Chemical carcinogenesishsa00900:Terpenoid backbone biosynthesis
AMPK signaling pathway
Bile secretionhsa00010:Glycolysis / Gluconeogenesis
Pentose and glucuronate interconversions
Degradation of aromatic compoundshsa00330:Arginine and proline metabolism
Calcium signaling pathway
Circadian entrainment
Long-term depression
Salivary secretion
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)hsa00140:Steroid hormone biosynthesis
Ovarian steroidogenesis
NetPath Pathway TGF_beta_Receptor Signaling PathwayNetPath_13:IL1 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling PathwayNetPath_13:IL1 Signaling Pathway
FSH Signaling PathwayNetPath_17:IL5 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
TSH Signaling PathwayNetPath_4:EGFR1 Signaling PathwayNetPath_25:FSH Signaling Pathway
PANTHER Pathway Cholesterol biosynthesisP06959:CCKR signaling map STP02727:Androgen/estrogene/progesterone biosynthesis
PathWhiz Pathway Folate Metabolism
Pterine BiosynthesisPW000044:Arachidonic Acid MetabolismPW000025:Fructose and Mannose Degradation
Pyruvate Metabolism
Pterine Biosynthesis
Glycerolipid Metabolism
Galactose MetabolismPW000055:Pentose Phosphate Pathway
Warburg EffectPW000141:SteroidogenesisPW000050:Steroid BiosynthesisPW000010:Arginine and Proline MetabolismPW000045:Androgen and Estrogen Metabolism
Reactome E2F mediated regulation of DNA replication
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Metabolism of folate and pterines
G1/S-Specific TranscriptionR-HSA-975634:Retinoid metabolism and transportR-HSA-5628897:TP53 Regulates Metabolic GenesR-HSA-194002:Glucocorticoid biosynthesisR-HSA-1222556:ROS production in response to bacteria
Nitric oxide stimulates guanylate cyclaseR-HSA-2453902:The canonical retinoid cycle in rods (twilight vision)
WikiPathways Metapathway biotransformation
Benzo(a)pyrene metabolism
Arachidonic acid metabolismWP702:Metapathway biotransformation
Polyol Pathway
Metabolism of steroid hormones and vitamin DWP692:Sulfation Biotransformation Reaction
NRF2 pathway
Nuclear Receptors Meta-Pathway
Vitamin D Receptor Pathway
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
Cori Cycle
Metabolism of carbohydrates
Pentose Phosphate Pathway
Glutathione metabolismWP98:Prostaglandin Synthesis and Regulation
Metabolism of steroid hormones and vitamin D
Glucocorticoid & Mineralcorticoid MetabolismWP430:Statin Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Activation of Gene Expression by SREBP (SREBF)
SREBF and miR33 in cholesterol and lipid homeostasis
Integrated Breast Cancer Pathway
SREBP signalling
Cholesterol BiosynthesisWP702:Metapathway biotransformation
Benzo(a)pyrene metabolismWP727:Monoamine Transport
Myometrial Relaxation and Contraction Pathways
Amyotrophic lateral sclerosis (ALS)
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
Spinal Cord Injury
Alzheimers Disease
Effects of Nitric Oxide
Serotonin Transporter ActivityWP496:Steroid Biosynthesis
Prostate Cancer
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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