Target Information

Target General Infomation
Target ID
T66976
Former ID
TTDS00060
Target Name
Alcohol dehydrogenase
Gene Name
AKR1A1
Synonyms
Aldehyde reductase; Aldo-keto reductase family 1 member A1; AKR1A1
Target Type
Research
Function
Catalyzes the NADPH-dependent reductionof a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).
BioChemical Class
Short-chain dehydrogenases reductases
Target Validation
T66976
UniProt ID
P14550
EC Number
EC 1.1.1.2
Sequence
MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL
KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER
GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP
AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK
YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV
PMLTVDGKRVPRDAGHPLYPFNDPY
Inhibitor 2'-Monophosphoadenosine 5'-Diphosphoribose Drug Info [551393]
3,5-dichlorosalicylic acid Drug Info [529899]
Nicotinamide-Adenine-Dinucleotide Drug Info [551393]
Trifluoroethanol Drug Info [551391]
Pathways
BioCyc Pathway Superpathway of tryptophan utilization
Tryptophan degradation via tryptamine
KEGG Pathway Glycolysis / Gluconeogenesis
Pentose and glucuronate interconversions
Glycerolipid metabolism
Metabolic pathways
Biosynthesis of antibiotics
Degradation of aromatic compounds
WikiPathways Metapathway biotransformation
Benzo(a)pyrene metabolism
References
Ref 529899Bioorg Med Chem. 2009 Feb 1;17(3):1244-50. Epub 2008 Dec 24.Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase.
Ref 551391DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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