TTD | Drug: D0J4MU

Drug General Information
Drug ID	D0J4MU
Former ID	DIB020444
Drug Name	MRS2957
Synonyms	MRS 2957
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541196]
Structure		Download 2D MOL
Formula	C19H28N5O20P3
InChI	InChI=1S/C19H28N5O20P3/c1-38-22-10-2-4-23(18(30)20-10)16-14(28)12(26)8(41-16)6-39-45(32,33)43-47(36,37)44-46(34,35)40-7-9-13(27)15(29)17(42-9)24-5-3-11(25)21-19(24)31/h2-5,8-9,12-17,26-29H,6-7H2,1H3,(H,32,33)(H,34,35)(H,36,37)(H,20,22,30)(H,21,25,31)/t8-,9-,12+,13+,14+,15+,16-,17-/m1/s1
InChIKey	SIKKMGJHOOQSAP-AOUMTEFLSA-N
PubChem Compound ID	91827347
Target and Pathway
Target(s)	P2Y purinoceptor 6	Target Info	Agonist	[530896]
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	G alpha (q) signalling events
Reactome	P2Y receptors
WikiPathways	Nucleotide GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 541196	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5903).
Ref 530896	Pyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications. J Med Chem. 2010 Jun 10;53(11):4488-501.

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Drug Information