Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0J8OW
|
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| Former ID |
DIB018069
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| Drug Name |
(+)-MCPG
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| Synonyms |
alpha-Mcpg; alpha-methyl-4-carboxyphenylglycine; alpha-methyl-cpgly
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [538851] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C10H11NO4
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| InChI |
InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)/t10-/m0/s1
|
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| InChIKey |
DNCAZYRLRMTVSF-JTQLQIEISA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
822933, 3153208, 7888849, 7980669, 10299878, 11111462, 11113453, 11113454, 15121146, 15438905, 24896589, 26751683, 36888802, 56311609, 57404739, 75202077, 91721441, 103562064, 104088255, 104636336, 124880723, 135610257, 135650572, 162249582, 163125594, 204429518, 237694018, 241037857, 241181624, 241376420
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| Target and Pathway | |||||
| Target(s) | Metabotropic glutamate receptor 2 | Target Info | Antagonist | [534581] | |
| Metabotropic glutamate receptor 5 | Target Info | Antagonist | [525911] | ||
| Metabotropic glutamate receptor3 | Target Info | Antagonist | [525619] | ||
| Metabotropic glutamate receptor 7 | Target Info | Antagonist | [525945] | ||
| Metabotropicglutamate receptor 1 | Target Info | Antagonist | [526599] | ||
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Glutamatergic synapse | |||||
| Cocaine addictionhsa04020:Calcium signaling pathway | |||||
| Gap junction | |||||
| Long-term potentiation | |||||
| Retrograde endocannabinoid signaling | |||||
| Huntington's diseasehsa04080:Neuroactive ligand-receptor interaction | |||||
| Cocaine addictionhsa04080:Neuroactive ligand-receptor interaction | |||||
| Glutamatergic synapsehsa04020:Calcium signaling pathway | |||||
| FoxO signaling pathway | |||||
| Long-term depression | |||||
| Estrogen signaling pathway | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Ionotropic glutamate receptor pathway | |||||
| Metabotropic glutamate receptor group II pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Metabotropic glutamate receptor group III pathway | |||||
| Metabotropic glutamate receptor group I pathway | |||||
| Endogenous cannabinoid signalingP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| Metabotropic glutamate receptor group II pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| Metabotropic glutamate receptor group III pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Endogenous cannabinoid signaling | |||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | ||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR downstream signalingWP501:GPCRs, Class C Metabotropic glutamate, pheromone | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| Ref 525619 | [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells. Neuropharmacology. 1999 Oct;38(10):1519-29. | ||||
| Ref 525911 | Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601. | ||||
| Ref 525945 | Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54. | ||||
| Ref 526599 | [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol Pharmacol. 2003 May;63(5):1082-93. | ||||
| Ref 534581 | Characterization of [3H]-(2S,2'R,3'R)-2-(2',3'-dicarboxy-cyclopropyl)glycine ([3H]-DCG IV) binding to metabotropic mGlu2 receptor-transfected cell membranes. Br J Pharmacol. 1998 Feb;123(3):497-504. | ||||
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