Drug General Information
Drug ID	D0JV2S
Former ID	DNC009705
Drug Name	VU0119498
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[542615]
Structure		Download 2D MOL 3D MOL
Formula	C15H10BrNO2
InChI	InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2
InChIKey	DELLOEULSHGYCG-UHFFFAOYSA-N
PubChem Compound ID	3008304
PubChem Substance ID	3720113, 7696867, 10038742, 12093808, 24360518, 26184285, 36057090, 57857327, 80556958, 81072527, 85285464, 89384916, 103613991, 104109119, 104793879, 111624248, 117387640, 124744854, 127116807, 131389383, 134346910, 143911986, 164326965, 170064040, 184024190, 223365967, 225159324, 231261309, 249355225
Target and Pathway
Target(s)	Muscarinic acetylcholine receptor M5	Target Info	Inhibitor	[530133]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Cholinergic synapse
	Regulation of actin cytoskeleton
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome	Muscarinic acetylcholine receptors
	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 542615	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7632).
Ref 530133	J Med Chem. 2009 Jun 11;52(11):3445-8.Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins.

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