TTD | Drug: D0L4HL

Drug General Information
Drug ID	D0L4HL
Former ID	DNCL003112
Drug Name	RG7314
Indication	Autism [ICD9: 299; ICD10:F84.0]		Phase 2	[524213]
Target and Pathway
Target(s)	Vasopressin V1a receptor	Target Info	Modulator	[544372]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
Reactome	Vasopressin-like receptors
Reactome	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 524213	ClinicalTrials.gov (NCT01793441) A Study of RG7314 to Investigate Efficacy and Safety in Individuals With Autism Spectrum Disorders. U.S. National Institutes of Health.
Ref 544372	Social Communication is an Emerging Target for Pharmacotherapy in Autism Spectrum Disorder - A Review of the Literature on Potential Agents. J Can Acad Child Adolesc Psychiatry. 2014 February; 23(1):20-30.

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Drug Information