Drug General Information
Drug ID	D0L8TN
Former ID	DIB003958
Drug Name	BU-4514N
Drug Type	Small molecular drug
Indication	Alzheimer disease [ICD9: 331; ICD10:G30]		Terminated	[545876]
Company	Bristol-Myers Squibb Co
Structure		Download 2D MOL 3D MOL
Formula	C27H42N2O5
Canonical SMILES	C1(C(=O)C2=C(CNC2=O)O)(C(C(=CC2C1CCC(C2)C)C)CC(OC1OC(C(<br />CC1)N)C)C)C
CAS Number	CAS 151013-39-7
PubChem Compound ID	54704416
Target and Pathway
Target(s)	Tumor necrosis factor receptor superfamily member 16	Target Info	Modulator	[533988]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	Cytokine-cytokine receptor interaction
	PI3K-Akt signaling pathway
	Neurotrophin signaling pathway
	Transcriptional misregulation in cancer
Pathway Interaction Database	p75(NTR)-mediated signaling
	Neurotrophic factor-mediated Trk receptor signaling
Reactome	Axonal growth inhibition (RHOA activation)
	NRAGE signals death through JNK
	p75NTR negatively regulates cell cycle via SC1
	Regulated proteolysis of p75NTR
	NADE modulates death signalling
	NRIF signals cell death from the nucleus
	p75NTR recruits signalling complexes
	NF-kB is activated and signals survival
	Axonal growth stimulation
WikiPathways	Spinal Cord Injury
	BDNF signaling pathway
	Signalling by NGF
References
Ref 545876	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005173)
Ref 533988	A new neuritogenetic compound BU-4514N produced by Microtetraspora sp. J Antibiot (Tokyo). 1993 Jun;46(6):875-83.

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