Drug General Information
Drug ID	D0N5HO
Former ID	DIB008211
Drug Name	SQ-32709
Drug Type	Small molecular drug
Indication	Arteriosclerosis [ICD9: 440; ICD10:I70]		Discontinued in Phase 2	[545908]
Company	Bristol-Myers Squibb Co
Structure		Download 2D MOL 3D MOL
Formula	C15H28O7P2
Canonical SMILES	P(=O)(OP(=O)(O)O)(COC/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)O
CAS Number	CAS 372-97-4
PubChem Compound ID	445713
Target and Pathway
Target(s)	Squalene synthetase	Target Info	Modulator	[526027]
BioCyc Pathway	Cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
	Cholesterol biosynthesis III (via desmosterol)
	Cholesterol biosynthesis I
	Superpathway of cholesterol biosynthesis
	Epoxysqualene biosynthesis
KEGG Pathway	Steroid biosynthesis
	Metabolic pathways
	Biosynthesis of antibiotics
PANTHER Pathway	Cholesterol biosynthesis
PathWhiz Pathway	Steroid Biosynthesis
Reactome	Cholesterol biosynthesis
	PPARA activates gene expression
	Activation of gene expression by SREBF (SREBP)
WikiPathways	Statin Pathway
	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
	Activation of Gene Expression by SREBP (SREBF)
	SREBP signalling
	Cholesterol Biosynthesis
	Cholesterol biosynthesis
References
Ref 545908	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005302)
Ref 526027	Clinical pharmacokinetics and pharmacodynamics of a new squalene synthase inhibitor, BMS-188494, in healthy volunteers. J Clin Pharmacol. 1998 Dec;38(12):1116-21.

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