Drug Information

Drug General Information
Drug ID
D0OK5I
Former ID
DAP000836
Drug Name
Tridihexethyl
Synonyms
Pathilon; Propethonum; (3-cyclohexyl-3-hydroxy-3-phenylpropyl)-triethylazanium; 3-cyclohexyl-N,N,N-triethyl-3-hydroxy-3-phenylpropan-1-aminium
Drug Type
Small molecular drug
Indication Acquired nystagmus [ICD9: 379.5; ICD10:H55] Approved [538420]
Therapeutic Class
Anticholinergic Agents
Structure
Download
2D MOL

3D MOL
Formula
C21H36NO+
Canonical SMILES
CC[N+](CC)(CC)CCC(C1CCCCC1)(C2=CC=CC=C2)O
InChI
1S/C21H36NO/c1-4-22(5-2,6-3)18-17-21(23,19-13-9-7-10-14-19)20-15-11-8-12-16-20/h7,9-10,13-14,20,23H,4-6,8,11-12,15-18H2,1-3H3/q+1
InChIKey
NPRHVSBSZMAEIN-UHFFFAOYSA-N
CAS Number
CAS 60-49-1
PubChem Compound ID
20299
PubChem Substance ID
10063, 6866978, 8165019, 11467070, 11468190, 11486638, 29287806, 46506672, 47350663, 47500807, 48020281, 48395176, 49699262, 50124071, 56464110, 57330601, 75127849, 85209972, 104350227, 117612552, 128736684, 131273739, 134221938, 134338116, 135022078, 137102175, 160963851, 179225204, 226471859
ChEBI ID
ChEBI:9701
SuperDrug ATC ID
A03AB08
SuperDrug CAS ID
cas=000060491
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M5 Target Info Binder [537342]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538420FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 009489.
Ref 537342Effect of anticholinergic agents upon acquired nystagmus: a double-blind study of trihexyphenidyl and tridihexethyl chloride. Neurology. 1991 Nov;41(11):1737-41.

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