Drug Information

Drug General Information
Drug ID
D0P1FJ
Former ID
DNC000245
Drug Name
Aprophen
Drug Type
Small molecular drug
Indication Discovery agent Investigative [536212], [537749]
Structure
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2D MOL

3D MOL
Formula
C21H27NO2
Canonical SMILES
CCN(CC)CCOC(=O)C(C)(C1=CC=CC=C1)C2=CC=CC=C2
InChI
1S/C21H27NO2/c1-4-22(5-2)16-17-24-20(23)21(3,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15H,4-5,16-17H2,1-3H3
InChIKey
DIDYGLSKVUKRRP-UHFFFAOYSA-N
CAS Number
CAS 3563-01-7
PubChem Compound ID
71128
PubChem Substance ID
6310258, 8194443, 14951174, 29216370, 43127515, 50025618, 57318020, 57825662, 79687531, 81093318, 85209440, 88826488, 103193266, 103919137, 104349726, 108205614, 126424253, 127738368, 134222727, 134339721, 135026637, 144205532, 164235787, 165805006, 170466081, 179294171, 198989935, 228472588, 249950688
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M5 Target Info Antagonist [536212], [537749]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 536212M1 muscarinic antagonists interact with sigma recognition sites. Life Sci. 1991;49(17):1229-35.
Ref 537749The muscarinic antagonists aprophen and benactyzine are noncompetitive inhibitors of the nicotinic acetylcholine receptor. Mol Pharmacol. 1987 Nov;32(5):678-85.
Ref 536212M1 muscarinic antagonists interact with sigma recognition sites. Life Sci. 1991;49(17):1229-35.
Ref 537749The muscarinic antagonists aprophen and benactyzine are noncompetitive inhibitors of the nicotinic acetylcholine receptor. Mol Pharmacol. 1987 Nov;32(5):678-85.

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