Drug Information

Drug General Information
Drug ID
D0R1WR
Former ID
DAP001110
Drug Name
Procyclidine
Synonyms
Arpicolin; Elorine; Kemadrin; Kemadrine; Lergine; Metanin; Osnervan; Prociclidina; Procidlidina; Procyclid; Procyclidinum; Procyklidin; Prosyklidin; Spamol; Triciclidina; Triciloid; Tricoloid; Tricyclamol; Vagosin; Prociclidina [INN-Spanish]; Procyclidine (INN); Procyclidine [INN:BAN]; Procyclidinum [INN-Latin]; 1-Cyclohexyl-1-phenyl-3-(1-pyrrolidinyl)-1-propanol; 1-Cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol; 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol
Drug Type
Small molecular drug
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Approved [538423], [542300]
Therapeutic Class
Antiparkinson Agents
Structure
Download
2D MOL

3D MOL
Formula
C19H29NO
InChI
InChI=1S/C19H29NO/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20/h1,3-4,9-10,18,21H,2,5-8,11-16H2
InChIKey
WYDUSKDSKCASEF-UHFFFAOYSA-N
CAS Number
CAS 77-37-2
PubChem Compound ID
4919
PubChem Substance ID
9582, 442081, 5236621, 7980394, 8153029, 10535550, 11335604, 11360843, 11363756, 11366318, 11368880, 11371833, 11374116, 11377042, 11461815, 11466872, 11467992, 11485071, 11486484, 11489114, 11490373, 11492304, 11494676, 14873275, 29223997, 46505553, 47365126, 47588938, 47588939, 47736414, 47810688, 47885350, 48184941, 48416474, 49698884, 50039088, 56464114, 57322525, 74962058, 85209950, 85787327, 96025111, 99233240, 103845996, 103958121, 104307795, 117612564, 117613088, 123087813, 124883429
ChEBI ID
ChEBI:8448
SuperDrug ATC ID
N04AA04
SuperDrug CAS ID
cas=000077372
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M5 Target Info Antagonist [535950]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538423FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 009818.
Ref 542300(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7280).
Ref 535950Protection against soman-induced seizures in rats: relationship among doses of prophylactics, soman, and adjuncts. Toxicol Appl Pharmacol. 2004 May 1;196(3):327-36.

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