Drug Information

Drug General Information
Drug ID
D0R8FS
Former ID
DNC012350
Drug Name
7-Dimethylamino-hept-5-yn-2-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551235]
Structure
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2D MOL

3D MOL
Formula
C9H15NO
Canonical SMILES
CC(=O)CCC#CCN(C)C
InChI
1S/C9H15NO/c1-9(11)7-5-4-6-8-10(2)3/h5,7-8H2,1-3H3
InChIKey
UYTLBASHEWACKP-UHFFFAOYSA-N
PubChem Compound ID
19816
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M4 Target Info Inhibitor [551235]
Muscarinic acetylcholine receptor M5 Target Info Inhibitor [551235]
Muscarinic acetylcholine receptor M2 Target Info Inhibitor [551235]
Muscarinic acetylcholine receptor M1 Target Info Inhibitor [551235]
Muscarinic acetylcholine receptor M3 Target Info Inhibitor [551235]
KEGG Pathway Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
cAMP signaling pathway
PI3K-Akt signaling pathway
Regulation of actin cytoskeleton
Insulin secretion
Salivary secretion
Gastric acid secretion
Pancreatic secretion
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00003:Alzheimer disease-amyloid secretase pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
PathWhiz Pathway Muscle/Heart ContractionPW000565:Gastric Acid Production
Reactome Muscarinic acetylcholine receptors
G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
GPCR downstream signaling
GPCRs, OtherWP58:Monoamine GPCRs
Secretion of Hydrochloric Acid in Parietal Cells
Integration of energy metabolism
GPCRs, Other
References
Ref 551235Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992).
Ref 551235Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992).

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