Drug General Information
Drug ID
D0RD5W
Former ID
DAP001108
Drug Name
Hyoscyamine
Synonyms
ATROPINE; Anaspaz; Atropair; Atropen; Atropin; Atropina; Atropinol; Atropt; Atrosulf; Belladenal; Buwecon; Cystospaz; Cytospaz; Daturine; Donnamar; Duboisine; Egacene; Egazil; Eyesules; Gastrosed; Hyocyamine; Hyospaz; Hyosyne; Levbid; Levsin; Levsinex; Minims; Neoquess; Nulev; OIN; Peptard; Symax; Urised; Atropin [German]; Atropina [Italian]; Atropine Care; Atropine [BAN]; HYOSCYAMINE HCl; Hyoscyamine [BAN]; Hyoscyamine sulfate; Isopto Atropine; Levsin SL; Levsinex SR; Minims Atropine; Scopolia extract; Symax Duotab; Symax SL; Symax SR; Tropine tropate; Troyl tropate; H 9002; Anaspaz (TN); Atropen (TN); Atropin-flexiolen; Atropine (USP); Bellergal-S; Buscopan (TN); Buwecon (TN); Cystospaz (TN); DL-Hyoscyamine; DL-Tropyl tropate; Dl-Hyoscyamine; Dl-Tropyltropate; Donnamar (TN); HyoMax (TN); Hyoscyamine (L); Hyoscyamine (USP); Hyospasmol (TN); I-Tropine; Isopto-atropine; L-Atropine; L-Hyopscyamine;L-Hyoscamine; L-Hyoscyamine; L-Hyoscyamine hydrobromide; L-Tropine tropate; Levbid (TN); Levsin (TN); NP-010662; Neo-Diophen; Neoquess (TN); NuLev (TN); Ocu-Tropine; Protamine & Atropine; Symax (TN);Tropic acid, ester with tropine; Tropine, tropate (ester); Atropine Sulfate S.O.P.; Tropic acid, 3-alpha-tropanyl ester; Atropine, 3(S)-endo-Isomer; DL-Tropanyl 2-hydroxy-1-phenylpropionate; R-(+)-Hyoscyamine; Tropine, (-)-tropate; Tropic acid, (-)-, ester with tropine; Tropine (+/-)-tropate; Tropine, (-)-tropate (ester); (+)-Atropine; (+)-HYOSCYAMINE; (+,-)-Tropyl tropate; (+-)-atropine; (+-)-hyoscyamine; (+/-)-Atropine; (+/-)-Hyoscyamine; (-)-Atropine; (-)-Hyoscyamine; (-)-Tropic Acid Ester with Tropine; (S)-(-)-Hyoscyamine; (S)-Atropine; 1-Hyoscyamine
Drug Type
Small molecular drug
Indication Gastrointestinal disease [ICD10:K00-K93] Approved [536224]
Therapeutic Class
Antiarrhythmic Agents
Structure
Download
2D MOL

3D MOL

Formula
C17H23NO3
Canonical SMILES
CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3
InChI
1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15?,16?
InChIKey
RKUNBYITZUJHSG-PJPHBNEVSA-N
CAS Number
CAS 101-31-5
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:17486
SuperDrug ATC ID
A03BA03
SuperDrug CAS ID
cas=000101315
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M5 Target Info Antagonist [537734]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 536224Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313.
Ref 537734Reconstitution of the purified porcine atrial muscarinic acetylcholine receptor with purified porcine atrial inhibitory guanine nucleotide binding protein. Biochemistry. 1987 Dec 15;26(25):8175-82.

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