Drug Information

Drug General Information
Drug ID
D0RG3O
Former ID
DAP000377
Drug Name
Atropine
Synonyms
Anaspaz; Atropair; Atropen; Atropin; Atropina; Atropinol; Atropt; Atrosulf; Belladenal; Cytospaz; Eyesules; Hyoscyamine; Minims; Tropanol; Urised; Atropin [German]; Atropina [Italian]; Atropine Care; Atropine [BAN]; Atropinium cation; Hyoscyamine sulfate; Isopto Atropine; Minims Atropine; Tropine tropate; Troyl tropate; OR22908; A-Tropine; Atropen (TN); Atropin-flexiolen; Atropine (USP); Bellergal-S; D1-hyoscyamine; DL-Tropyl tropate; Dl-Hyoscyamine; Dl-Tropyltropate; I-Tropine; Isopto-atropine; Lomotil (TN); NP-010662; Neo-Diophen; Ocu-Tropine; Protamine & Atropine; Tropic acid, ester with tropine; Atropinium(1+); Tropan-3alpha-ol; Tropan-3beta-ol; Tropine, tropate (ester); Atropine Sulfate S.O.P.; Tropic acid, 3-alpha-tropanyl ester; DL-Tropanyl 2-hydroxy-1-phenylpropionate; Beta-Phenyl-gamma-oxypropionsaeure-tropyl-ester [German]; Beta-Phenyl-gamma-oxypropionsaure-tropyl-ester [German]; Tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate; Tropine (+/-)-tropate; Endo-8-methyl-8-azabicyclo[3.2.1]octan-3-ol; B eta-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester; [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate; [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoate; Endo-(+/-)-alpha-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester; Benzeneacetic acid, alpha-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester; (+,-)-Tropyl tropate; (+-)-atropine; (+-)-hyoscyamine; (+/-)-Atropine; (+/-)-Hyoscyamine; (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl (2S)-3-hydroxy-2-phenylpropanoate; (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate; (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate; (3-endo)-8-methyl-8-azabicyclo[3.2.1]octan-3-ol; (3-endo,8-syn)-3-[(3-hydroxy-2-phenylpropanoyl)oxy]-8-methyl-8-azoniabicyclo[3.2.1]octane; (3-exo)-8-methyl-8-azabicyclo[3.2.1]octan-3-ol; 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (+-)-tropate (ester); 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (+-)-tropate (ester) (8CI); 1alphaH,5alphaH-Tropan-3alpha-ol; 1alphaH,5alphaH-Tropan-3alpha-ol (+-)-tropate (ester); 1alphaH,5alphaH-Tropan-3beta-ol; 2-Phenylhydracrylic acid 3-alpha-tropanyl ester; 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate; 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl tropate; 8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropionate
Drug Type
Small molecular drug
Indication Organophosphate poisoning [ICD9: 989.3; ICD10:T60.0] Approved [538234], [540179]
Poison intoxication [ICD10:T36-T50] Phase 1 [534497], [540179], [551871]
Therapeutic Class
Antiarrhythmic Agents
Company
Pfizer Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C17H23NO3
InChI
InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?
InChIKey
RKUNBYITZUJHSG-SPUOUPEWSA-N
CAS Number
CAS 51-55-8
PubChem Compound ID
174174
PubChem Substance ID
4651, 814306, 841226, 7837579, 7847181, 7978742, 8144950, 10258016, 11533003, 16376693, 24890401, 24890659, 26754302, 29215197, 33498346, 36511844, 46476231, 46507540, 47359794, 48253833, 48413242, 48415591, 49857189, 53789078, 56313665, 56422449, 57352393, 75150730, 85788924, 85856317, 92308692, 93576972, 95156767, 104098724, 104169991, 104171350, 111677788, 113474904, 117475976, 118260686, 121362578, 124558762, 124799783, 124883031, 124883032, 124883033, 124883034, 129143706, 131408727, 134337687
ChEBI ID
ChEBI:16684
SuperDrug ATC ID
A03BA01; S01FA01
SuperDrug CAS ID
cas=000051558
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M5 Target Info Antagonist [535437], [537455], [537469], [537749]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 534497Potentiation and inhibition of neuronal nicotinic receptors by atropine: competitive and noncompetitive effects. Mol Pharmacol. 1997 Nov;52(5):886-95.
Ref 538234FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 071295.
Ref 540179(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 320).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535437The effects of the antagonists of muscarinic acetylcholine receptor subtypes in rat brain on urinary bladder contraction. Nippon Hinyokika Gakkai Zasshi. 2002 Mar;93(3):427-34.
Ref 537455Loss of M2 muscarinic receptor function inhibits development of hypoxic bradycardia and alters cardiac beta-adrenergic sensitivity in larval zebrafish (Danio rerio). Am J Physiol Regul Integr Comp Physiol. 2009 Aug;297(2):R412-20. Epub 2009 Jun 10.
Ref 537469Additive Protective Effects of Donepezil and Nicotine Against Salsolinol-Induced Cytotoxicity in SH-SY5Y Cells. Neurotox Res. 2009 Mar 20.
Ref 537749The muscarinic antagonists aprophen and benactyzine are noncompetitive inhibitors of the nicotinic acetylcholine receptor. Mol Pharmacol. 1987 Nov;32(5):678-85.

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