Drug Information

Drug General Information
Drug ID
D0RY4M
Former ID
DNC000757
Drug Name
Hyoscine
Drug Type
Small molecular drug
Indication Discovery agent Phase 4 [524694]
Structure
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2D MOL

3D MOL
Formula
C17H21NO4
Canonical SMILES
CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4
InChI
1S/C17H21NO4/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10/h2-6,11-16,19H,7-9H2,1H3/t11?,12?,13-,14-,15-,16+/m0/s1
InChIKey
STECJAGHUSJQJN-OYVHKFOJSA-N
CAS Number
CAS 1239-45-8
PubChem Compound ID
5809
PubChem Substance ID
29224842, 50045596, 76199430, 104310319, 134337654, 163076432
ChEBI ID
ChEBI:4883
SuperDrug ATC ID
A04AD01
SuperDrug CAS ID
cas=000051343
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M5 Target Info Antagonist [538039]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 524694ClinicalTrials.gov (NCT02098889) Safety Study of Hyoscine N Butyl Bromide in Active Management of Labor. U.S. National Institutes of Health.
Ref 538039Comparison of the effects of a selective muscarinic receptor antagonist and hyoscine (scopolamine) on motion sickness, skin conductance and heart rate. Br J Clin Pharmacol. 1997 Jun;43(6):633-7.

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