Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0T4UE
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| Former ID |
DNC009571
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| Drug Name |
Mycophenolic bis(sulfonamide)
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C13H18N2O8S2
|
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| Canonical SMILES |
CC1=C(C(=C(C2=C1COC2=O)O)CCNS(=O)(=O)CS(=O)(=O)N)OC
|
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| InChI |
1S/C13H18N2O8S2/c1-7-9-5-23-13(17)10(9)11(16)8(12(7)22-2)3-4-15-25(20,21)6-24(14,18)19/h15-16H,3-6H2,1-2H3,(H2,14,18,19)
|
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| InChIKey |
IVAOVFUEHDFBPQ-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Inosine-5'-monophosphate dehydrogenase 2 | Target Info | Inhibitor | [1] | |
| Inosine-5'-monophosphate dehydrogenase 1 | Target Info | Inhibitor | [1] | ||
| BioCyc Pathway | Purine nucleotides degradation | ||||
| Urate biosynthesis/inosine 5'-phosphate degradation | |||||
| Guanosine nucleotides de novo biosynthesis | |||||
| Superpathway of purine nucleotide salvage | |||||
| Purine nucleotides de novo biosynthesis | |||||
| Guanosine ribonucleotides de novo biosynthesisPWY-6353:Purine nucleotides degradation | |||||
| Guanosine ribonucleotides de novo biosynthesis | |||||
| KEGG Pathway | Purine metabolism | ||||
| Drug metabolism - other enzymes | |||||
| Metabolic pathwayshsa00230:Purine metabolism | |||||
| Metabolic pathways | |||||
| PANTHER Pathway | De novo purine biosynthesis | ||||
| PathWhiz Pathway | Purine Metabolism | ||||
| Reactome | Purine ribonucleoside monophosphate biosynthesisR-HSA-73817:Purine ribonucleoside monophosphate biosynthesis | ||||
| WikiPathways | Nucleotide Metabolism | ||||
| References | |||||
| REF 1 | Bioorg Med Chem. 2008 Aug 1;16(15):7462-9. Epub 2008 Jun 10.Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase. | ||||
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