Target Information
Target General Infomation | |||||
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Target ID |
T97713
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Former ID |
TTDS00401
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Target Name |
Inosine-5'-monophosphate dehydrogenase 1
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Gene Name |
PPAT
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Synonyms |
IMP dehydrogenase 1; IMPD 1; IMPD1; IMPDH-I; IMPDH1; PPAT
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Target Type |
Successful
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Disease | Organ transplant rejection [ICD9: 279.5, 996; ICD10: D89.8, T86] | ||||
BioChemical Class |
Short-chain dehydrogenases reductases
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Target Validation |
T97713
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UniProt ID | |||||
EC Number |
EC 1.1.1.205
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Sequence |
MELEELGIREECGVFGCIASGEWPTQLDVPHVITLGLVGLQHRGQESAGIVTSDGSSVPT
FKSHKGMGLVNHVFTEDNLKKLYVSNLGIGHTRYATTGKCELENCQPFVVETLHGKIAVA HNGELVNAARLRKKLLRHGIGLSTSSDSEMITQLLAYTPPQEQDDTPDWVARIKNLMKEA PTAYSLLIMHRDVIYAVRDPYGNRPLCIGRLIPVSDINDKEKKTSETEGWVVSSESCSFL SIGARYYREVLPGEIVEISRHNVQTLDIISRSEGNPVAFCIFEYVYFARPDSMFEDQMVY TVRYRCGQQLAIEAPVDADLVSTVPESATPAALAYAGKCGLPYVEVLCKNRYVGRTFIQP NMRLRQLGVAKKFGVLSDNFKGKRIVLVDDSIVRGNTISPIIKLLKESGAKEVHIRVASP PIKYPCFMGINIPTKEELIANKPEFDHLAEYLGANSVVYLSVEGLVSSVQEGIKFKKQKE KKHDIMIQENGNGLECFEKSGHCTACLTGKYPVELEW |
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Structure |
1JCN
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Drugs and Mode of Action | |||||
Pathways | |||||
BioCyc Pathway | Purine nucleotides degradation | ||||
Urate biosynthesis/inosine 5' | |||||
-phosphate degradation | |||||
Guanosine nucleotides de novo biosynthesis | |||||
Superpathway of purine nucleotide salvage | |||||
Purine nucleotides de novo biosynthesis | |||||
Guanosine ribonucleotides de novo biosynthesis | |||||
KEGG Pathway | Purine metabolism | ||||
Drug metabolism - other enzymes | |||||
Metabolic pathways | |||||
PathWhiz Pathway | Purine Metabolism | ||||
Reactome | Purine ribonucleoside monophosphate biosynthesis | ||||
WikiPathways | Nucleotide Metabolism | ||||
References | |||||
Ref 529172 | J Med Chem. 2007 Dec 27;50(26):6685-91. Epub 2007 Nov 27.Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment. | ||||
Ref 529565 | Bioorg Med Chem. 2008 Aug 1;16(15):7462-9. Epub 2008 Jun 10.Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase. | ||||
Ref 531203 | Bioorg Med Chem. 2010 Nov 15;18(22):8106-11. Epub 2010 Sep 18.Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells amongthe mycophenolic acid derivatives. | ||||
Ref 536171 | Immunosuppressive drugs and renal transplantation. G Ital Nefrol. 2005 Nov-Dec;22 Suppl 33:S76-9. |
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